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KMID : 0359720210390010001
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Journal of the Korean Neurological Association
2021 Volume.39 No. 1 p.1 ~ p.9
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Peripheral Neuropathy and Pain Caused by Cancer Chemotherapy
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Choi Kyo-Min
Oh Jee-Young
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Abstract
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Peripheral neuropathy and pain are common adverse effects of chemotherapy, which incidence are rising significantly commensurate with extension of survival period in cancer patients. Chemotherapy-induced peripheral neuropathy is caused by most commonly used chemotherapeutic agents including platinum compounds, taxenes, proteasome inhibitors, thalidomide, and vinca alkaloids. Management of neuropathy and pain caused by chemotherapy is still challenging due to there is no proven therapies and preventive methods. The pain and its impact are becoming a main deterioration factor in quality of life and economic burden in our society. We review the mechanism, clinical characteristics, updated evidence of possible management of neuropathy and pain caused by traditional chemotherapeutic agents for contributing to the application of clinicians in their actual medical environment.
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KEYWORD
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Antineoplastic agent, Polyneuropathies, Small fiber neuropathy, Vincristine, Paclitaxel
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